Antibiotics are medications designed to treat infection and which can kill bacteria that might have entered a wound or tissue.
In some cases, sciatica will be caused by infection. This might be an infection of the surrounding tissue, which can cause swelling and thereby place pressure on the sciatic nerve. In other cases however, it might also be an infection that is directly affecting the nerve itself. This can then cause pain, discomfort and numbness. Fortunately, antibiotics will generally solve the problem quickly.